Central nervous system involvement in primary bone marrow or splenic marginal zone lymphoma: Report of two cases and review of the literature.

We present two cases of splenic/primary bone marrow marginal zone lymphoma with secondary leptomeningeal CNS involvement, successfully treated with both systemic and intrathecal immunotherapy and we review the relevant literature. This complication is rare in this type of lymphomas at diagnosis or at relapse; as a rule, it seems to be the trigger for systemic disease. Leptomeningeal lymphomatous involvement in the context of systemic marginal zone lymphomas requires early recognition and it is associated with a favorable prognosis with non-intensive therapeutic measures, such as intrathecal immunotherapy.