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Spray-Dried pH Sensitive Microparticles: Effectual Methodology to Ameliorate the Bioavailability of Acid Labile Pravastatin.
Drug Development and Industrial Pharmacy 2018 December 22
Pravastatin is a promising drug utilized in the treatment of hyperlipidemia, yet, its main clinical limitation is due to gastric liability which fractions its oral bioavailability to less than 18%. The purpose of the current study is to encapsulate pravastatin into Eudragit®-based spray-dried microparticles aspiring to overcome its acid liability. With the aim to optimize the microparticles, formulation and process parameters were studied through acid resistance challenging test. Physicochemical characterization of the optimized spray-dried pH sensitive microparticles namely; in-vitro dissolution, surface morphology, compatibility and solid-state studies were performed. Moreover, in-vivo evaluation of the microparticles and accelerated stability studies were carried out.
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