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JOURNAL ARTICLE
REVIEW
Assessing the Evidence in Evidence-Based Medicine.
Nutrition in Clinical Practice 2019 Februrary
Evidence-based medicine (EBM) has become a fixture in today's medical practice. Evidence consists of memorialized observations and should be contrasted with dogmatic pronouncements and/or hypotheses. Evidence has varying degrees of reliability. The randomized clinical trial (RCT) or a systematic review of RCTs is accorded the highest level of credibility and expert opinion the lowest. This ranking reflects the internal validity (degree to which factors in the study interfere with the gathering or interpretation of the observations) of the study design; more valid designs are more credible. The provision of healthcare requires an almost constant assessment of evidence. In so doing, there are a number of principles of EBM that need to be kept in mind: Association can never prove causation. Various methodologic biases can influence conclusions made in both RCTs and observational studies. The strength of RCTs is in the elimination of confounding bias. Surrogate outcomes must be validated in RCTs assessing how they are changed compared with the clinical outcomes. Subgroup analyses cannot prove hypotheses although they can generate them. P < 0.05 is not the same as truth. Type I errors are more likely to occur when multiple analyses are performed, when trials are prematurely stopped for perceived benefit when there was no a priori plan to do so, or in small papers with dramatic results that are selectively published. The failure to find a difference does not mean that no difference exists (type II error).
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