Analysing the Secretome of Gut Microbiota as the Next Strategy For Early Detection of Colorectal Cancer.

Dysbiosis of gut microbiome can contribute to inflammation, and subsequently initiation and progression of colorectal cancer (CRC). Throughout these stages, various proteins and metabolites are secreted to the external environment by microorganisms or the hosts themselves. Studying these proteins may help enhance our understanding of the host-microorganism relationship or they may even serve as useful biomarkers for CRC. However, secretomic studies of gut microbiome of CRC patients, until now, are scarcely performed. In this viewpoint article, we focus on the roles of gut microbiome in CRC, highlight the current findings on CRC secretome and address the emerging challenges and strategies to drive forward this area of research. This article is protected by copyright. All rights reserved.