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In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.

Evelyn E Nash, Tara C Henning, Cau D Pham, Kevin Pettus, Samera Sharpe, Ellen N Kersh
Diagnostic Microbiology and Infectious Disease 2018 November 11
Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous.

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