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Towards the molecular deciphering of Pomacea canaliculata immunity: first proteomic analysis of circulating hemocytes.
Proteomics 2018 December 11
Pomacea canaliculata is a freshwater snail with interesting biological features that include invasiveness, human parasite hosting and adult regeneration. Its immune system may represent the target for strategies aimed at controlling the spread of the snail population and its hosting of the human parasite Angiostrongylus cantonensis. Moreover, immune functions likely have a role in the snail's ability to wound heal and regenerate. Despite its importance in multiple processes, very little is known about the molecular basis of P. canaliculata immunity. Aiming to contribute to filling this gap, we have studied the ultrastructure and performed the first proteomic analysis of circulating hemocytes in healthy snails, evidencing 83 unique proteins, 96% of which have identifiable homologs in other species. Fifteen proteins were retrieved as potentially involved in immune-related signaling pathways, including hemocyanin, C1q-like protein and HSP90 together with cytoskeleton and cytoskeleton-related proteins involved in cell motility and membrane dynamism. This first proteome study on non-stimulated hemocytes, provides a valid reference for future investigations on the molecular changes under stressful circumstances, like pathogen exposure, wounding or environmental changes. This article is protected by copyright. All rights reserved.
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