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Efficient drug discovery by rational lead hybridization based on crystallographic overlay.

Shuo Zhang, Jian Zhang, Ping Gao, Lin Sun, Yuning Song, Dongwei Kang, Xinyong Liu, Peng Zhan
Drug Discovery Today 2018 December 5
In this review, we provide an overview of recent applications of crystallographic overlay-based molecular structure hybridization of lead compounds as a rational strategy for efficient drug discovery, with selected examples, and briefly discuss its advantages compared with other ligand-based methodologies.

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