Hyperuricemia and prognosis of acute ischemic stroke in diabetic patients.

OBJECTIVES: The relationship between hyperuricemia (HUA) and prognosis of acute ischemic stroke (AIS) is unclear. This prospective cohort study aims to evaluate potential value of HUA as a prognostic factor for AIS independent of diabetic status.

METHODS: A total of 1041 consecutive patients aged from 25 to 96 with AIS were included. 340 (32.7%) had diabetes and 246 (23.6%) had HUA. Diabetic patients were stratified by gender or age. Multivariate logistic regression was used to analyse the association between HUA and prognosis of AIS.

RESULTS: HUA independently predicted poor discharge outcome of AIS in diabetic patients [OR (95% CI): 2.061 (1.042-4.077), p < 0.05]. Among diabetics, HUA selectively predicted a poor functional outcome of AIS at discharge in patients aged ≤75 years [OR (95% CI): 2.381 (1.115-5.085), p < 0.05]. Furthermore, in patients aged ≤75 years, HUA independently predicted poor discharge outcome of AIS in male diabetics [OR (95% CI): 2.684 (1.001-7.200), p < 0.05]. No association between HUA and prognosis of AIS was observed at 3-month, 6-month and 12-month follow-up, either in diabetics or nondiabetics.

CONCLUSIONS: HUA independently predicted poor in-hospital outcome of AIS in diabetic patients, especially in patients aged ≤ 75 years.