We have located links that may give you full text access.
Comparison of in vivo lung morphometry models from 3D multiple b-value 3 He and 129 Xe diffusion-weighted MRI.
Magnetic Resonance in Medicine 2018 December 5
PURPOSE: To compare in vivo lung morphometry parameters derived from theoretical gas diffusion models, the cylinder model and stretched exponential model, in a range of acinar microstructural length scales encountered in healthy and diseased lungs with 3 He and 129 Xe diffusion-weighted MRI.
METHODS: Three-dimensional multiple b-value 3 He and 129 Xe diffusion-weighted MRI was acquired with compressed sensing at 1.5 T from 51 and 31 subjects, respectively, including healthy volunteers, ex-smokers, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease patients. For each subject, the stretched exponential model-derived mean diffusive length scale (LmD ) was calculated from the diffusion signal decay, and was compared with the cylinder model-derived mean chord length (Lm) and mean alveolar diameter (LAlv ) in order to determine the relationships among the different lung morphometry parameters.
RESULTS: For both 3 He and 129 Xe diffusion-weighted MRI, the mean global LmD value was significantly related (P < .001) to Lm in a nonlinear power relationship, whereas the LAlv demonstrated excellent linear correlation (P < .001) with LmD . A mean bias of +1.0% and - 2.6% toward LmD was obtained for Bland-Altman analyses of 3 He and 129 Xe LmD and LAlv values, suggesting that the two morphometric parameters are equivalent measures of mean acinar dimensions.
CONCLUSION: Within the experimental range of parameters considered here for both 3 He and 129 Xe, the stretched exponential model-derived LmD is related nonlinearly to cylinder model-derived Lm, and demonstrates excellent agreement with the cylinder model-derived LAlv .
METHODS: Three-dimensional multiple b-value 3 He and 129 Xe diffusion-weighted MRI was acquired with compressed sensing at 1.5 T from 51 and 31 subjects, respectively, including healthy volunteers, ex-smokers, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease patients. For each subject, the stretched exponential model-derived mean diffusive length scale (LmD ) was calculated from the diffusion signal decay, and was compared with the cylinder model-derived mean chord length (Lm) and mean alveolar diameter (LAlv ) in order to determine the relationships among the different lung morphometry parameters.
RESULTS: For both 3 He and 129 Xe diffusion-weighted MRI, the mean global LmD value was significantly related (P < .001) to Lm in a nonlinear power relationship, whereas the LAlv demonstrated excellent linear correlation (P < .001) with LmD . A mean bias of +1.0% and - 2.6% toward LmD was obtained for Bland-Altman analyses of 3 He and 129 Xe LmD and LAlv values, suggesting that the two morphometric parameters are equivalent measures of mean acinar dimensions.
CONCLUSION: Within the experimental range of parameters considered here for both 3 He and 129 Xe, the stretched exponential model-derived LmD is related nonlinearly to cylinder model-derived Lm, and demonstrates excellent agreement with the cylinder model-derived LAlv .
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app