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Proliferation of Cells with Severe Nuclear Deformation on a Micropillar Array.
Langmuir : the ACS Journal of Surfaces and Colloids 2018 December 5
Cellular responses on a topographic surface are fundamental topics about Interfaces and Biology. Herein, a poly(lactide-co-glycolide) (PLGA) micropillar array was prepared and found to trigger significant self deformation of cell nuclei. The time-dependent cell viability and thus cell proliferation was investigated. Despite of significant nuclear deformation, all of the examined cell types (Hela, HepG2, MC3T3-E1 and NIH3T3) could survive and proliferate on the micropillar array, yet exhibited different proliferation abilities. Compared to the corresponding groups on the smooth surface, the cell proliferation abilities on the micropillar array were decreased for Hela and MC3T3-E1 cells, and did not change significantly for HepG2 and NIH3T3 cells. We further found that whether the proliferation ability changed or not was related to whether or not the nuclear sizes reduced in the micropillar array, and thus the size-deformation of cell nuclei should, besides shape-deformation, be taken into consideration in studies of cells on topological surfaces.
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