We have located links that may give you full text access.
Hypoxia-induced vagal withdrawal is independent of the hypoxic ventilatory response in men.
Journal of Applied Physiology 2018 November 30
Hypoxia increases heart rate (HR) in humans by sympathetic activation and vagal withdrawal. However, in anaesthetized dogs hypoxia increases vagal activity and reduces HR if pulmonary ventilation does not increase and we evaluated whether that observation applies to awake humans. Ten healthy males were exposed to 15 min of normoxia and hypoxia (10.5 % O2 ), while respiratory rate and tidal volume were volitionally controlled at values identified during spontaneous breathing in hypoxia. End-tidal CO2 tension was clamped at 40 mmHg by CO2 supplementation. β-adrenergic blockade by intravenous propranolol isolated vagal regulation of HR. During spontaneous breathing hypoxia increased ventilation by 3.2 ± 2.1 l min-1 (p = 0.0033) and HR by 8.9 ± 5.5 beats min-1 (p < 0.001). During controlled breathing, respiratory rate (16.3 ± 3.2 vs. 16.4 ± 3.3 breaths min-1 ) and tidal volume (1.05 ± 0.27 vs. 1.06 ± 0.24 l) were similar for normoxia and hypoxia, whereas the HR increase in hypoxia persisted without (8.6 ± 10.2 beats min-1 ) and with (6.6 ± 5.6 beats min-1 ) propranolol. Neither controlled breathing (p = 0.80), propranolol (p = 0.64), nor their combination (p = 0.89) affected the HR increase in hypoxia. Arterial pressure was unaffected (p = 0.48) by hypoxia across conditions. The hypoxia-induced increase in HR during controlled breathing and β-adrenergic blockade indicates that hypoxia reduces vagal activity in humans even when ventilation does not increase. Vagal withdrawal in hypoxia seems to be governed by the arterial chemoreflex rather than a pulmonary inflation reflex in humans.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app