Add like
Add dislike
Add to saved papers

Multifractal and Lacunarity Analyses of Microvascular Morphology in Eyes with Diabetic Retinopathy: A Projection Artifact Resolved Optical Coherence Tomography Angiography Study.

OBJECTIVE: To evaluate the degree of microvascular impairment in diabetic retinopathy using multifractal and lacunarity analyses and to compare the diagnostic ability between traditional Euclidean measures (fovea avascular zone area and vessel density) and fractal geometric features.

METHODS: This retrospective cross-sectional study included a total of 143 eyes of 94 patients with different stages of diabetic retinopathy. The retinal microvasculature was imaged by projection removed optical coherence tomography angiography. We examined the degree of association between fractal metrics of the retinal microvasculature and diabetic retinopathy severity. The area under the receiver operating characteristic curve was used to estimate the diagnostic performance.

RESULTS: With increasing diabetic retinopathy severity, the multifractal spectrum shifted towards the left bottom and exhibited less left skewness and asymmetry. The vessel density, multifractal features and lacunarity measured from the deep capillary plexus were strongly associated with diabetic retinopathy severity. The multifractal feature D5 showed the highest diagnostic ability. The combination of multifractal features further improved the discriminating power.

CONCLUSIONS: Multifractal and lacunarity analyses can be potentially valuable tools for assessment of microvascular impairments in diabetic retinopathy. Multifractal geometric parameters exhibit a better discriminatory performance than Euclidean measures, particularly for detection of the early stages of diabetic retinopathy. This article is protected by copyright. All rights reserved.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app