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Detailed efficiency analysis of columns with a different packing quality and confirmation via total pore blocking.
Journal of Chromatography. A 2018 November 2
We report on a systematic study involving columns with a clearly different efficiency (4 distinct quality groups) obtained by packing the columns that were C18 bonded and endcapped with a different carbon loading. Using B-term analysis (via peak parking) and theoretical models to estimate the magnitude of the Cm - and Cs -term contributions, it could be concluded that the difference in efficiency among the groups was entirely due to a difference in eddy dispersion. As such, the columns provided an ideal testing ground to verify how well the total pore blocking (TPB)-method can be used to probe differences in packing heterogeneity. In agreement with earlier literature observations, it turns out the TPB-method is much more sensitive to packing heterogeneities than the eddy dispersion (Heddy )-contribution measured under open-pore conditions via B- and C- term subtraction. Typically, differences in Heddy on the order of 0.1-0.5μm translate into a difference on the order of 0.5-2μm in the TPB mode. This confirms the TPB as a powerful technique to make very sensitive measurements of the homogeneity of packed beds.
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