Yanghe Huayan Decoction inhibit the capability of trans-endothelium and angiogenesis of HER2+ breast cancer via pAkt signaling.

BACKGROUND: Yanghe Huayan Decoction (YHD), a traditional Chinese medicine, is one of the most common complementary medicine currently used in the treatment of breast cancer. It has been recently linked to suppressing precancerous lesion and tumor development. The current study sought to explore the role of Yanghe Huayan Decoction on trans-endothelium and angiogenesis of breast cancer.

METHODS: HER2+ breast cancer cells were treated with YHD, Trastuzumab or the combination in vitro and in vivo to compare the effects of them on trans-endothelium and angiogenesis features. This study also investigated the potential molecular mechanism of YHD in inhibiting angiogenesis of breast cancer.

RESULTS: YHD significantly suppressed the invasion and angiogenesis of breast cancer cells via elevated pAkt signaling. Administration of YHD in vivo also strikingly repressed angiogenesis in tumor grafts.

CONCLUSION: YHD could partially inhibit and reverse tumorigenesis of breast cancer. It also could inhibit Akt activation and angiogenesis in vitro and in vivo Its effect was superior to trastuzumab. Thus it was suitable in prevention and treatment for breast cancer.