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RNA Therapeutics for Tissue Engineering.

Elizabeth R Balmayor, Christopher Evans
Tissue Engineering. Part A 2018 November 15
RNA has several theoretical advantages as a therapeutic agent, but exploiting RNA in this fashion has faced several major hurdles. RNA is unstable and difficult to deliver across hydrophobic cell membranes. Moreover, extraneous RNAs activate innate immune nucleic acid sensors which make them toxic and inflammatory.

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