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Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
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Specimen Pooling as a Diagnostic Strategy for Microbiologic Confirmation in Children with Intrathoracic Tuberculosis.

Elisabetta Walters, Marieke M van der Zalm, Anne-Marie Demers, Andrew Whitelaw, Megan Palmer, Corné Bosch, Heather R Draper, H Simon Schaaf, Pierre Goussard, Carl J Lombard, Robert P Gie, Anneke C Hesseling
Pediatric Infectious Disease Journal 2019 June
Three-hundred four young children with suspected pulmonary tuberculosis had a gastric aspirate, induced sputum and nasopharyngeal aspirate collected on each of 2 consecutive weekdays. Specimens collected on the second day were pooled in the laboratory for each child individually. The diagnostic yield by Xpert and culture from pooled specimens was not significantly different to a single gastric aspirate.

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