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A survey of software tool utilization and capabilities for quantitative systems pharmacology: what we have and what we need.
CPT: Pharmacometrics & Systems Pharmacology 2018 November 13
Quantitative Systems Pharmacology is a rapidly emerging discipline with application across a spectrum of challenges facing the pharmaceutical industry, including mechanistically informed prioritization of target pathways and combinations in discovery, target population and dose expansion decisions early in clinical development, and analyses for regulatory authorities late in clinical development. Quantitative Systems Pharmacology's development has influences from physiologic modeling, systems biology, physiologically-based pharmacokinetic modeling, and pharmacometrics. Given a varied scientific heritage, a variety of tools to accomplish the demands of model development, application, and model-based analysis of available data have been developed. We report the outcome from a community survey and resulting analysis of how modelers view the impact and growth of Quantitative Systems Pharmacology, how they utilize existing tools, and capabilities they need improved to further accelerate their impact on drug development. These results serve as a benchmark and roadmap for advancements to the Quantitative Systems Pharmacology tool set. This article is protected by copyright. All rights reserved.
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