Add like
Add dislike
Add to saved papers

High-Dimensional Inference for Personalized Treatment Decision.

Recent development in statistical methodology for personalized treatment decision has utilized high-dimensional regression to take into account a large number of patients' covariates and described personalized treatment decision through interactions between treatment and covariates. While a subset of interaction terms can be obtained by existing variable selection methods to indicate relevant covariates for making treatment decision, there often lacks statistical interpretation of the results. This paper proposes an asymptotically unbiased estimator based on Lasso solution for the interaction coefficients. We derive the limiting distribution of the estimator when baseline function of the regression model is unknown and possibly misspecified. Confidence intervals and p-values are derived to infer the effects of the patients' covariates in making treatment decision. We confirm the accuracy of the proposed method and its robustness against misspecified function in simulation and apply the method to STAR*D study for major depression disorder.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app