We have located links that may give you full text access.
Incidence of single-drug-, multidrug-, and extensively drug-antimicrobial resistance of Escherichia coli urinary tract infections: an Australian laboratory-based retrospective study.
Journal of Global Antimicrobial Resistance 2018 November 7
OBJECTIVES: To evaluate incidence of single-drug resistant, multidrug-resistant, extensively drug-resistant and pandrug-resistant E. coli urinary tract infections (UTI) in a sample of Australian Capital Territory (ACT) residents.
METHODS: We utilised laboratory-based retrospective data from all ACT residents whose urine samples were processed from January 2009 to December 2013. Multivariate logistic regression models were constructed to determine the associations of age, sex, urine sample source and socioeconomic status with risk of resistant infections.
RESULTS: A total of 146,915 urine samples from 57,837 ACT residents were identified over five years. Mean age of people in the sample was 48 years (standard deviation=26years) and 64.4% were females. Five-year incidence of single-drug resistant E. coli UTI was high for ampicillin, trimethoprim and cefazolin (6.8%, 3.5% and 1.9% respectively). No pandrug-resistant E. coli UTI was detected. Five-year incidences of multidrug- and extensively drug-resistant E. coli UTI were 1.9% and 0.2% respectively, which is low in comparison to international rates. Female sex and age over 38 years were significantly associated with single- and multidrug-resistance. Compared to hospitals, office-hours general practices, community and specialist health services, risk of single-drug resistance was significantly higher in samples from after-hours general practices (adjusted-odds ratio (OR) and 95% confidence intervals (CI) 2.6 (2.2-3.1)).
CONCLUSIONS: Our findings have significant implications for antimicrobial prescribing given identified risk factors for the detection of resistance, especially in patients attending after-hours general practices.
METHODS: We utilised laboratory-based retrospective data from all ACT residents whose urine samples were processed from January 2009 to December 2013. Multivariate logistic regression models were constructed to determine the associations of age, sex, urine sample source and socioeconomic status with risk of resistant infections.
RESULTS: A total of 146,915 urine samples from 57,837 ACT residents were identified over five years. Mean age of people in the sample was 48 years (standard deviation=26years) and 64.4% were females. Five-year incidence of single-drug resistant E. coli UTI was high for ampicillin, trimethoprim and cefazolin (6.8%, 3.5% and 1.9% respectively). No pandrug-resistant E. coli UTI was detected. Five-year incidences of multidrug- and extensively drug-resistant E. coli UTI were 1.9% and 0.2% respectively, which is low in comparison to international rates. Female sex and age over 38 years were significantly associated with single- and multidrug-resistance. Compared to hospitals, office-hours general practices, community and specialist health services, risk of single-drug resistance was significantly higher in samples from after-hours general practices (adjusted-odds ratio (OR) and 95% confidence intervals (CI) 2.6 (2.2-3.1)).
CONCLUSIONS: Our findings have significant implications for antimicrobial prescribing given identified risk factors for the detection of resistance, especially in patients attending after-hours general practices.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app