We have located links that may give you full text access.
Interruption in membrane permeability of drug-resistant Staphylococcus aureus with cationic particles of nano‑silver.
European Journal of Pharmaceutical Sciences 2018 November 8
The increasing drug-resistance pathogens among gram-positive bacterial species are becoming a major health concern nowadays. Over the past few years, the bactericidal efficacy of nano‑silver against some drug-resistant gram-positive bacteria has been established, however further investigation is needed to determine whether nano‑silver could be an option for the treatment of drug-resistant gram-positive microbial infections. The purpose of the present study was to determine the bactericidal efficacy of nano‑silver with its membrane destroying property using drug-resistant Staphylococcus aureus MTCC 3160. In the present study, bactericidal assessment of nano‑silver with different antibiotics was determined by agar well diffusion method. Interaction of nano‑silver towards bacterial membrane was carried to understand the probable bactericidal actions of nano‑silver, which was further confirmed by respiratory chain dehydrogenase, zeta potential, Scanning Electron Microscopy (SEM) and Gas Chromatography-Mass Spectrometry (GC-MS). The effect of nano‑silver on bacterial Deoxyribonucleic Acids (DNA) was evaluated by agarose gel electrophoresis. Bactericidal assessment of nano‑silver showed a very strong bactericidal action compare to antibiotics. The binding affinity of nano‑silver towards bacterial membrane induced loss of catalytic activity for respiratory chain dehydrogenases. Zeta potential, SEM and GC-MS analysis also revealed extensive damage to the bacterial cell membrane. Moreover, the analysis of agarose gel electrophoresis revealed that nano‑silver can enhance the decomposability of bacterial DNA, which was directly attached to the bacterial cell membrane. The present findings suggested that nano‑silver directly interact with the bacterial cell surface without the need to penetrate; and this distinctive property raises the hope that nano‑silver will remain an important bactericide in bacteria than antibiotics.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app