We have located links that may give you full text access.
Development and in vitro evaluation of a self-emulsifying drug delivery system (SEDDS) for oral vancomycin administration.
International Journal of Pharmaceutics 2018 November 6
The aim of this study was to develop a self-emulsifying drug delivery system (SEDDS) containing the glycopeptide antibiotic vancomycin (VAN) with improved intestinal mucosa permeating properties in order to increase oral drug absorption. VAN was effectively incorporated into SEDDS increasing the lipophilicity of the drug via hydrophobic ion pairing (HIP) with cetyltrimethylammonium bromid (CTAB). Newly developed SEDDS formulations containing VAN/CTAB complex were characterized with respect to droplet size, polydispersity index and zeta potential. Furthermore, permeating properties were investigated in porcine intestinal mucus using Transwell setup and on freshly excised porcine intestinal mucosa utilizing Ussing-type chamber. In addition, minimum inhibitory concentration (MIC) of VAN/CTAB-SEDDS against Staphylococcus aureus was evaluated. The developed formulations F1 (25% Capmul 808G EP/NF, 37.5% Cremophor RH 40, 37.5%), F2 (26.5% Capmul 808G EP/NF, 33.2% Cremophor RH 40, 13.8% Transcutol, 26.5% DMSO) and F3 (28.8% Captex 8000, 35% Cremophor EL, 20% Transcutol, 16.2% DMSO) with a mean droplet size of 14 nm, 15 nm and 153 nm, respectively, exhibited improved ability to permeate porcine intestinal mucosal barrier. F1-VAN/CTAB showed 219-fold, F2-VAN/CTAB 46-fold and F3-VAN/CTAB 63-fold higher permeation of VAN through the mucus layer after 4 h in comparison to free VAN. Moreover, all formulations demonstrated a 4-8-fold improvement in permeation of intestinal mucosa compared to free VAN solution. Additionally, F2-VAN/CTAB with a MIC of 0.313 mg/L showed higher effectivity against S. aureus (ATCC® 29213) compared to free VAN. According to these results, HIP combined with SEDDS should be taken into consideration as promising tool for oral antibiotic delivery.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app