SNW1 as a novel transcriptional regulator of the NF-κB pathway.

The nuclear factor-kappa B (NF-κB) family of transcription factors plays a central role in coordinating the expression of genes that control inflammation, immune responses, cell-proliferation, and a variety of other biological processes. In an attempt to identify novel regulators of this pathway, we performed whole-genome RNAi screens in physiologically relevant human macrophages in response to Lipopolysaccharides and Tumor Necrosis Factor Alpha. The top hit was SNW1, a splicing factor and transcriptional co-activator.