We have located links that may give you full text access.
Changing the pill: developments towards the promise of an ultra long-acting gastroretentive dosage form.
Expert Opinion on Drug Delivery 2018 November 6
INTRODUCTION: The development of oral sustained release dosage forms has been a longstanding goal due to the potential for ease of administration, improved pharmacokinetics, reduced dosing frequency, and improved adherence. The benefits of multi-day single dose drug delivery are evident in the success and patient adoption of injected or implanted dosage forms. However, in the space of oral medications, all current commercially-available gastric resident dosage forms, and most in development, are limited to gastric residence of less than one day. Areas covered: Reviews of systems to extend gastric residence reveals that one-day or more residence has been an unmet challenge. New dosage forms are in development that seek to address many of the key physiological and design challenges of long-term gastric retention beyond 24 hours and up to a week or longer. The present analysis highlights the design, material considerations, and implications of unfolding dosage form systems with ultra-long-term gastric residence. Expert opinion: The development of oral dosage forms providing sustained release of high potency medications over days or weeks could transform care, significantly decrease patient burden in chronic disease management and improve outcomes.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app