Predictors of Long-term Adverse Events After Absorb Bioresorbable Vascular Scaffold Implantation: A 1,933-Patient Pooled Analysis From International Registries.

AIMS: To investigate the predictors of long-term adverse clinical events after implantation of the everolimus-eluting Absorb bioresorbable vascular scaffold (BVS).

METHODS AND RESULTS: We pooled patient-level databases derived from the large-scale ABSORB EXTEND study and five high-volume international centers. Between November 2011 and November 2015, 1,933 patients underwent PCI with a total of 2,372 Absorb BVS implanted. The median age was 61.0 (IQR 53.0 to 68.6) years, 24% had diabetes, 68.2% presented with stable coronary artery disease. At a median follow-up of 616 days, MACE occurred in 93 (4.9%) patients, all-cause death in 36 (1.9%) patients, myocardial infarction in 47 (2.5%) patients, and target vessel revascularization in 72 (3.8%) patients. Definite or probable scaffold thrombosis occurred in 26 (1.3%) patients. On multivariable logistic regression analysis, acute coronary syndromes (hazard ratio [HR]: 2.79, 95% confidence interval [CI]: 1.47 to 5.29; p=0.002), dyslipidemia (HR: 1.43, 95% CI: 1.23 to 1.79; p=0.007), scaffold/reference diameter ratio >1.25 (HR: 1.49, 95% CI: 1.18 to 1.88; p=0.001), and residual stenosis >15% (HR: 1.67, 95% CI: 1.34 to 2.07; p<0.001) were independent predictors of MACE, whereas the use of intravascular imaging was independently associated with a reduction in MACE (HR: 0.13, 95% CI: 0.06 to 0.28; p<0.001).

CONCLUSIONS: Optimal Absorb BVS implantation and the use of intravascular imaging guidance were associated to lower rates of adverse events at long-term follow-up.