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Mixture of Two Lactobacillus plantarum Strains Modulates the Gut Microbiota Structure and Regulatory T Cell Response in Diet-Induced Obese Mice.

SCOPE: The gut microbiota has been linked to diet-induced obesity, and microorganisms that influence obesity have important health implications. In this study, the anti-obesity effects of two Lactobacillus plantarum strains (DSR M2 and DSR 920) isolated from kimchi were investigated.

METHODS AND RESULTS: Mice were fed a normal or high-fat diet with or without DSR M2 and DSR 920 (DSR, 1 × 109 CFU/day) for 12 weeks. DSR improved the obesity state, as evidenced by the (i) suppressed obesity-related markers, e.g., gains in body weight and fat mass, (ii) reduced serum and liver triglyceride levels, (iii) up-regulated β-oxidation and down-regulated lipogenesis-related genes in the liver, (iv) reduced serum leptin levels, (v) altered microbial communities, (vi) increased regulatory T cell immunity, and (vii) suppressed inflammatory response. In addition, correlation analysis showed that Akkermansia muciniphila and the genus Anaerostipes which were increased in the DSR group were negatively correlated with obesity-related markers, but Mucispirillum schaedleri which was increased in the HFD group was positively correlated with serum leptin level.

CONCLUSION: Lactobacillus plantarum DSR M2 and DSR 920 are candidate probiotics for the prevention and amelioration of obesity. This article is protected by copyright. All rights reserved.

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