[CLINICAL EFFICIENCY OF CYCLOFERON IN CHILDREN AND ADULTS WITH HIV AND/ OR HERPES INFECTION: SYSTEMATIC REVIEW AND META-ANALYSIS].

Aim was to estimate and compare clinical efficiency of cycloferon use against basic therapy in treatment of HIV and/ or herpes infection. There were comparisons of treatment results with patient (n=1274) groups' heterogeneity taken into account. 9 randomized clinical trials with cycloferon efficacy data were mobilized, in all studies there were protocols of injections, tablets or liniments cycloferon administration. Homogeneous and symmetric groups combination during meta-analysis increased statistic power of comparisons and led to integrative efficiency assessment, proved its' stability in statistic models. Cycloferon use in children and adults with HIV and/ or herpes infection was more the 3 times more effective to provide stable remission and exacerbation frequency diminish against basic therapy.