Association between muscle strength, histopathology and MRI in sIBM.

OBJECTIVES: Inclusion body myositis is characterized by inflammatory and degenerative changes, but the temporal relation of these events is unknown.

MATERIALS AND METHODS: In nineteen patients with inclusion body myositis muscle strength was correlated with inflammatory and degenerative findings on MRI and in muscle biopsies in three different muscles (tibialis anterior, vastus lateralis, biceps brachii). Muscle strength, measured with a hand-held dynamometer, was described as percentage of muscle strength in age and sex matched normal individuals. The muscles were categorized as the strongest, the intermediate and the weakest muscle in each individual. T1-weighted sequences on MRI were used to evaluate the degree of fatty infiltration and muscle atrophy and STIR sequences to evaluate edematous changes.

RESULTS: The vastus lateralis, which in general was the weakest muscle, was significantly more atrophic compared to the other two muscles and also demonstrated most edema. The biceps brachii had in most cases an intermediate degree of weakness and atrophy but the most pronounced inflammatory cell infiltration on biopsy. Cytochrome c oxidase negative muscle fibers were significantly more prevalent in the vastus lateralis and biceps brachii muscles than in the tibialis anterior and thus correlated with muscular atrophy, indicating that this is a secondary change. Inflammatory changes as assessed by MRI and muscle biopsy were seen in all muscles irrespective of atrophy and thus appear to be prevalent at all stages of the disease.

CONCLUSIONS: Our study could not provide an answer to the question which comes first, the inflammation or the degenerative changes. This article is protected by copyright. All rights reserved.