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Full genome-based genotyping system for rotavirus H and detection of potential gene recombination in nonstructural protein 3 between porcine rotavirus H and rotavirus C.

Rotavirus species H (RVH) has been detected in pigs, humans and bats. Moreover, porcine RVHs have often been identified in several swine-producing countries in recent years. Despite their zoonotic impact, genome information for RVHs is still limited. This study aimed to establish a tentative complete genome-based genotyping system for RVH by appending genomic sequences from 12 porcine RVHs identified in Japan between 2013 and 2015 to those from human and other porcine RVHs reported in previous studies. Phylogenetic analysis of 11 RNA segments indicated that porcine RVHs could be classified into multiple genotypes. Consequently, the genotype classification for RVHs revealed the existence of genotypes 10G, 6P, 6I, 3R, 4C, 7M, 6A, 2N, 4T, 6E and 3H for the genes VP7, VP4, VP6, VP1, VP2, VP3, NSP1, NSP2, NSP3, NSP4 and NSP5, respectively. Surprisingly, two distinctive types of NSP1 and NSP3 genes were identified from among the 12 porcine RVHs. Our data suggest a potentially novel gene recombination event between porcine RVH and rotavirus species C in the NSP3 gene. These findings would provide a new insight into the evolution of rotavirus.

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