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Effect of oral magnesium sulfate administration on LOX-1 gene expression to prevent atherosclerosis in diabetic rat vessels.

INTRODUCTION: The purpose of this study was to investigate the possible effect of oral magnesium sulfate (MgSO4 ) in reduction of atherosclerosis plaques via inhibition of LOX-1 gene expression in diabetic vessels.

MATERIAL AND METHODS: Fifty rats were divided into five groups including non-diabetic control (NDC); Mg-treated non-diabetic control (Mg -NDC); chronic diabetic (CD); Mg-treated chronic diabetic (Mg-CD); and insulin- treated chronic diabetic (Ins-CD). The induction of diabetes was performed by streptozotocin. The Mg-CD and Mg-NDC groups were treated with 10g/l of MgSO4 added to their drinking water. The Ins-CD group received 2.5 U/kg of insulin twice per day. The fasting blood glucose level and body weight were determined weekly. The blood pressure measuring and intraperitoneal glucose tolerance test (IPGTT) were performed after 16 weeks the plasma levels of Mg, lipid profile and oxLDL were determined. Mesenteric bed was isolated and perfused according to McGregor method. Aorta was isolated for LOX-1 genes and proteins expression and pathologic investigation.

RESULTS: MgSO4 administration improved blood pressure, sensitivity to phenylephrine, IPGTT, lipid profile and plasma ox-LDL level and also lowered the blood glucose level to the normal range and decreased LOX-1 gene and protein expressions. Insulin decreased blood pressure, sensitivity to phenylephrine, blood glucose, lipid profiles and plasma oxLDL level but it did not decrease LOX-1 gene and protein expressions.

CONCLUSION: Our findings suggested that Mg improves blood pressure and vessel structure via decreasing oxLDL and LOX-1 gene and protein expressions, however insulin did not repair vessel structure and LOX-1 gene and protein expressions. This article is protected by copyright. All rights reserved.

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