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CRISPR-PLANT v2: An online resource for highly specific guide RNA spacers based on improved off-target analysis.
Plant Biotechnology Journal 2018 October 17
Since the beginning of CRISPR/Cas9's use for genome-editing, reports of off-targets have caused concerns among users. Previous studies identified three main types of off-targets. The first type of off-targets are sequences at other 5'-NGG-3' protospacer adjacent motifs (PAMs) that are identical or have a small number of mismatches or substitutions (Fu et al., 2013; Tsai et al., 2015). The second type of off-targets are sequences at other 5'-NGG-3' PAMs that have insertions or deletions compared to the gRNA spacer or the targeted DNA (Lin et al., 2014). This article is protected by copyright. All rights reserved.
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