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Prolonged stimulation of β 2 -adrenergic receptor with β 2 -agonists impairs insulin actions in H9c2 cells.
Journal of Pharmacological Sciences 2018 November
Insulin resistance is a condition in which there is a defect in insulin actions to induce glucose uptake into the cells. Overstimulation of β2 -adrenergic receptors (β2 ARs) is associated with the pathogenesis of insulin resistance in the heart. However, the mechanisms by which β2 -agonists affect insulin resistance in the heart are incompletely understood. The β2 -agonists are used for treatment of asthma due to bronchodilating effects. We also investigated the effects of β2 -agonists in human bronchial smooth muscle (HBSM) cells. In this study, we demonstrate that chronic treatment with salbutamol, salmeterol, and formoterol inhibited insulin-induced glucose uptake and GLUT4 synthesis in H9c2 myoblast cells. Sustained β2 AR stimulation also attenuated GLUT4 translocation to the plasma membrane, whereas short-term stimulation had no effect. In HBSM cells, prolonged treatment with β2 -agonists had no effect on insulin-induced glucose uptake and did not alter insulin-induced expressions of GLUT1, GLUT4, and GLUT10. In addition, genetic polymorphisms at amino acid positions 16 and 27 of β2 AR are linked to insulin resistance by significant suppression of GLUT4 translocation compared to wild-type. Thus, prolonged β2 AR stimulation by β2 -agonists impairs insulin actions through suppression of GLUT synthesis and translocation only in H9c2 cells.
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