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A cross-sectional retrospective study to analyze the underlying causes and clinical characteristics of children with reactive thrombocytosis at a Korean tertiary medical center.
Blood Research 2018 September
BACKGROUND: Reactive thrombocytosis (RT) is a common condition among children, although no studies have examined the etiology or clinical characteristics of RT among Korean children.
METHODS: This retrospective study evaluated children with RT at a single Korean tertiary center during a 10-year period.
RESULTS: RT accounted for 13.5% of children who were admitted to the pediatric ward (4,113/30,355): mild RT, 82.7%; moderate RT, 14.1%; severe RT, 1.1%; and extreme RT, 2.1%. There was a negative correlation between platelet count and Hb level ( P =0.008). There were positive correlations between platelet count and WBC ( P =0.001), erythrocyte sedimentation rate (ESR) ( P =0.007), and admission duration ( P =0.006). The most common cause of RT was infection and the second most common was Kawasaki disease (KD). The highest proportion of lower respiratory tract infection was observed in extreme RT ( P <0.001). The proportion of KD was highest in extreme RT ( P <0.001) and in children aged 1-7.9 years ( P <0.001). The proportion of refractory KD was highest in extreme RT ( P =0.005). In cases of KD, there was a positive correlation between platelet count and fever duration ( P =0.006). Non-KD autoimmune inflammation was only observed in mild/moderate RT, and its proportion was highest in children aged 8-18 years ( P <0.001).
CONCLUSION: In children, more severe RT was associated with lower Hb, increased WBC, ESR, and prolonged admission. With respiratory infection or KD, extreme RT was associated with more severe disease course.
METHODS: This retrospective study evaluated children with RT at a single Korean tertiary center during a 10-year period.
RESULTS: RT accounted for 13.5% of children who were admitted to the pediatric ward (4,113/30,355): mild RT, 82.7%; moderate RT, 14.1%; severe RT, 1.1%; and extreme RT, 2.1%. There was a negative correlation between platelet count and Hb level ( P =0.008). There were positive correlations between platelet count and WBC ( P =0.001), erythrocyte sedimentation rate (ESR) ( P =0.007), and admission duration ( P =0.006). The most common cause of RT was infection and the second most common was Kawasaki disease (KD). The highest proportion of lower respiratory tract infection was observed in extreme RT ( P <0.001). The proportion of KD was highest in extreme RT ( P <0.001) and in children aged 1-7.9 years ( P <0.001). The proportion of refractory KD was highest in extreme RT ( P =0.005). In cases of KD, there was a positive correlation between platelet count and fever duration ( P =0.006). Non-KD autoimmune inflammation was only observed in mild/moderate RT, and its proportion was highest in children aged 8-18 years ( P <0.001).
CONCLUSION: In children, more severe RT was associated with lower Hb, increased WBC, ESR, and prolonged admission. With respiratory infection or KD, extreme RT was associated with more severe disease course.
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