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Plasma level of YKL-40 correlates with the severity of coronary atherosclerosis assessed with SYNTAX score.

Introduction YKL-40 is a protein released locally by inflammatory cells. Thus, it may constitute a biomarker of inflammatory conditions, such as atherosclerosis. Objectives To determine the YKL-40 level in patients with ischemic heart disease, and to analyze the correlation of this biomarker with the severity of coronary atherosclerosis. Patients and methods The study included 158 patients, among them 52 with stable ischemic heart disease and 67 with an acute coronary syndrome: ST elevation (STEMI) and non-ST elevation myocardial infarction (NSTEMI). Control group was comprised of 39 persons without abnormalities in coronary vessels. The analysis included plasma concentration of YKL-40 in the study patients and its correlation with the severity of coronary atherosclerosis assessed with SYNTAX score. Results Patients with myocardial infarction presented with significantly higher plasma concentrations of YKL-40 than persons with stable ischemic disease [235.3 (161.6-366.1) ng/ml vs. 61.2 (53.1-83.1) ng/ml; P<0.000001] and the controls [235.3 (161.6-366.1) ng/ml vs. 55.7 (51.2-75.2) ng/ml; P<0.000001]. No statistically significant differences were found in YKL-40 protein concentrations in STEMI and NSTEMI patients [263 (150.3-363.7) ng/ml vs. 214.9 (163.4-367.6) ng/ml; P=0.7]. SYNTAX scores in the whole group of patients with ischemic heart disease correlated positively with their YKL-40 concentrations [r=0.34; P<0.00001]. Conclusion YKL-40 can be considered a potential biomarker of coronary atherosclerosis severity.

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