Add like
Add dislike
Add to saved papers

Glucocorticoid-Induced Leucine Zipper Promotes Neutrophil and T Cell Polarization with Protective Effects in Acute Kidney Injury.

The glucocorticoid-induced leucine zipper (GILZ) mediates anti-inflammatory effects of glucocorticoids. Acute kidney injury (AKI) mobilizes immune/inflammatory mechanisms, causing tissue injury, but GILZ's impact in AKI is not known. Neutrophils play context-specific pro- (N1) and anti-inflammatory (N2) functional roles. Also, regulatory T lymphocytes (Tregs) and regulatory T-17 (Treg17) cells exert counter-inflammatory effects including suppression of effector T lymphocytes, e.g., Th-17 cells. Thus, utilizing cell preparations of mice kidneys subjected to AKI or sham operation, we determined the effects of GILZ on T cells and neutrophil subtypes in the context of its renoprotective effect; these studies utilized the trans activator of transcription (TAT)-GILZ or the TAT peptide. AKI increased N1 and Th-17 cells but reduced N2, Tregs and Treg17 cells in association with increased interleukin (IL)-17+ but reduced IL-10+ cells accompanied with disruption of mitochondrial membrane potential (ψm) and increased apoptosis/necrosis compared to sham kidneys. TAT-GILZ, compared to TAT, treatment reduced N1 and Th-17 cells but increased N2 and Tregs, without affecting Treg17 cells, in association with reduction in IL-17+ but increased IL-10+ cells; TAT-GILZ caused less disruption of ψm and reduced cell death in AKI. Importantly, TAT-GILZ increased perfusion of the ischemic-reperfused kidney but reduced tissue edema compared to TAT. Utilizing splenic T cells and bone marrow-derived neutrophils, we further showed marked reduction in proliferation of Th cells in response to TAT-GILZ than TAT. Collectively, the results indicate that GILZ exerts renoprotection accompanied with upregulation of regulatory/suppressive arm of immunity in AKI likely via regulating crosstalk between T cells and neutrophils.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app