We have located links that may give you full text access.
Discordance in risk factors for the progression of diabetic retinopathy and diabetic nephropathy in patients with type 2 diabetes mellitus.
Journal of Diabetes Investigation 2018 October 10
AIMS: We aimed to investigate whether there are differences in the risk factors or markers for the progression of diabetic retinopathy (DR) and diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM).
MATERIALS AND METHODS: We conducted a 3-year retrospective cohort study on 604 patients with T2DM mellitus. The outcomes were the progression of DR (worsening of the DR stage) and DN [an estimated glomerular filtration rate (eGFR) decline >12%] at the 3-year follow-up. Mean hemoglobin A1c (HbA1c) level, and HbA1c variability (HbA1c-VAR) were calculated.
RESULTS: Mean HbA1c and HbA1c-VAR levels were higher in the DR progressors (n = 67) than in the DR nonprogressors (n = 537). Mean HbA1c was a significant predictor for DR progression independent of the duration of diabetes and HbA1c-VAR levels. The urine albumin to creatinine ratio (ACR) at baseline and HbA1c-VAR levels were higher in the DN progressors (n = 34) than in the DN nonprogressors (n = 570). The triglyceride to high-density lipoprotein (HDL) cholesterol ratio at baseline tended to be higher in the DN progressors than in the DN nonprogressors. HbA1c-VAR levels and triglyceride to HDL cholesterol ratio were significant predictors for the DN progression independent of eGFR and urine ACR.
CONCLUSIONS: Average glycemia was significantly associated with progression of DR, whereas glycemic variability and dyslipidemia were significantly associated with progression of DN in T2DM. This article is protected by copyright. All rights reserved.
MATERIALS AND METHODS: We conducted a 3-year retrospective cohort study on 604 patients with T2DM mellitus. The outcomes were the progression of DR (worsening of the DR stage) and DN [an estimated glomerular filtration rate (eGFR) decline >12%] at the 3-year follow-up. Mean hemoglobin A1c (HbA1c) level, and HbA1c variability (HbA1c-VAR) were calculated.
RESULTS: Mean HbA1c and HbA1c-VAR levels were higher in the DR progressors (n = 67) than in the DR nonprogressors (n = 537). Mean HbA1c was a significant predictor for DR progression independent of the duration of diabetes and HbA1c-VAR levels. The urine albumin to creatinine ratio (ACR) at baseline and HbA1c-VAR levels were higher in the DN progressors (n = 34) than in the DN nonprogressors (n = 570). The triglyceride to high-density lipoprotein (HDL) cholesterol ratio at baseline tended to be higher in the DN progressors than in the DN nonprogressors. HbA1c-VAR levels and triglyceride to HDL cholesterol ratio were significant predictors for the DN progression independent of eGFR and urine ACR.
CONCLUSIONS: Average glycemia was significantly associated with progression of DR, whereas glycemic variability and dyslipidemia were significantly associated with progression of DN in T2DM. This article is protected by copyright. All rights reserved.
Full text links
Trending Papers
Acute and non-acute decompensation of liver cirrhosis (47/130).Liver International : Official Journal of the International Association for the Study of the Liver 2024 March 2
Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM).Clinical Infectious Diseases 2024 March 6
Ten Influential Point-of-Care Ultrasound Papers: 2023 in Review.Journal of Intensive Care Medicine 2024 Februrary 20
Administration of methylene blue in septic shock: pros and cons.Critical Care : the Official Journal of the Critical Care Forum 2024 Februrary 17
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app