We have located links that may give you full text access.
Discordance in risk factors for the progression of diabetic retinopathy and diabetic nephropathy in patients with type 2 diabetes mellitus.
Journal of Diabetes Investigation 2018 October 10
AIMS: We aimed to investigate whether there are differences in the risk factors or markers for the progression of diabetic retinopathy (DR) and diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM).
MATERIALS AND METHODS: We conducted a 3-year retrospective cohort study on 604 patients with T2DM mellitus. The outcomes were the progression of DR (worsening of the DR stage) and DN [an estimated glomerular filtration rate (eGFR) decline >12%] at the 3-year follow-up. Mean hemoglobin A1c (HbA1c) level, and HbA1c variability (HbA1c-VAR) were calculated.
RESULTS: Mean HbA1c and HbA1c-VAR levels were higher in the DR progressors (n = 67) than in the DR nonprogressors (n = 537). Mean HbA1c was a significant predictor for DR progression independent of the duration of diabetes and HbA1c-VAR levels. The urine albumin to creatinine ratio (ACR) at baseline and HbA1c-VAR levels were higher in the DN progressors (n = 34) than in the DN nonprogressors (n = 570). The triglyceride to high-density lipoprotein (HDL) cholesterol ratio at baseline tended to be higher in the DN progressors than in the DN nonprogressors. HbA1c-VAR levels and triglyceride to HDL cholesterol ratio were significant predictors for the DN progression independent of eGFR and urine ACR.
CONCLUSIONS: Average glycemia was significantly associated with progression of DR, whereas glycemic variability and dyslipidemia were significantly associated with progression of DN in T2DM. This article is protected by copyright. All rights reserved.
MATERIALS AND METHODS: We conducted a 3-year retrospective cohort study on 604 patients with T2DM mellitus. The outcomes were the progression of DR (worsening of the DR stage) and DN [an estimated glomerular filtration rate (eGFR) decline >12%] at the 3-year follow-up. Mean hemoglobin A1c (HbA1c) level, and HbA1c variability (HbA1c-VAR) were calculated.
RESULTS: Mean HbA1c and HbA1c-VAR levels were higher in the DR progressors (n = 67) than in the DR nonprogressors (n = 537). Mean HbA1c was a significant predictor for DR progression independent of the duration of diabetes and HbA1c-VAR levels. The urine albumin to creatinine ratio (ACR) at baseline and HbA1c-VAR levels were higher in the DN progressors (n = 34) than in the DN nonprogressors (n = 570). The triglyceride to high-density lipoprotein (HDL) cholesterol ratio at baseline tended to be higher in the DN progressors than in the DN nonprogressors. HbA1c-VAR levels and triglyceride to HDL cholesterol ratio were significant predictors for the DN progression independent of eGFR and urine ACR.
CONCLUSIONS: Average glycemia was significantly associated with progression of DR, whereas glycemic variability and dyslipidemia were significantly associated with progression of DN in T2DM. This article is protected by copyright. All rights reserved.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app