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Cholangiocyte-to-Hepatocyte Differentiation: a Context Dependent Process and an Opportunity for Regenerative Medicine.
Hepatology : Official Journal of the American Association for the Study of Liver Diseases 2018 October 9
The liver owns an extraordinary regenerative capacity to compensate functional mass loss after acute cytotoxic injury or surgical resection. Hepatic mass restoration following hepatocellular or cholangiocellular injury is commonly mediated by the proliferation and replenishment of the existing differentiated hepatocytes and biliary epithelial cells (BECs or cholangiocytes), respectively. However, during chronic hepatocellular damage, the long-term cell renewal capacity of differentiated hepatocytes becomes compromised. This article is protected by copyright. All rights reserved.
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