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Serum Uric Acid Levels in Type 2 Diabetes Mellitus: Is There a Linear Relationship with Severity of Carotid Atherosclerosis?
Indian Journal of Endocrinology and Metabolism 2018 September
Aims: The aim of this study was to correlate serum uric acid (SUA) levels and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (DM).
Settings and Design: This study was a cross-sectional observational study on 103 diabetic patients conducted from September 2015 to May 2017.
Subjects and Methods: We screened 103 patients with type 2 DM between the ages of 30-65 years. SUA levels and the CIMT were measured. The patients were divided into quartiles based on uric acid level. The CIMT of the quartiles is compared and analyzed.
Statistical Analysis Used: Chi-squared test, Analysis of Variance, and Pearson's correlation.
Results: Uric acid levels were positively associated with CIMT ( P = 0.001). The association remained significant after further adjustment for potential confounders. Strong correlation was found among them as depicted by correlation coefficient (r = 0.779).
Conclusions: Carotid atherosclerosis as measured by IMT is associated with SUA levels in patients with type 2 DM.
Settings and Design: This study was a cross-sectional observational study on 103 diabetic patients conducted from September 2015 to May 2017.
Subjects and Methods: We screened 103 patients with type 2 DM between the ages of 30-65 years. SUA levels and the CIMT were measured. The patients were divided into quartiles based on uric acid level. The CIMT of the quartiles is compared and analyzed.
Statistical Analysis Used: Chi-squared test, Analysis of Variance, and Pearson's correlation.
Results: Uric acid levels were positively associated with CIMT ( P = 0.001). The association remained significant after further adjustment for potential confounders. Strong correlation was found among them as depicted by correlation coefficient (r = 0.779).
Conclusions: Carotid atherosclerosis as measured by IMT is associated with SUA levels in patients with type 2 DM.
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