We have located links that may give you full text access.
Alterations in serum zinc and polyunsaturated fatty acid concentrations in treatment naïve HIV-diagnosed alcohol dependent subjects with liver injury.
AIDS Research and Human Retroviruses 2018 October 4
Heavy alcohol drinking causes alterations in the metabolism of fatty acids and zinc that participate in inflammation and liver injury. Human Immunodeficiency Virus (HIV) infection has been reported to cause dysregulated polyunsaturated fatty acid (PUFAs) and zinc metabolism. In this pilot study, we examined the role of dysregulated PUFA metabolism and zinc deficiency in liver injury in the liver injury occurring in heavy drinkers with early stage HIV diagnosis. Fourteen heavy drinking alcohol dependent (AD) patients (seven with treatment naïve HIV diagnosis [AD+HIV], and seven without HIV infection [AD]) participated in this study. Liver injury, serum zinc, PUFAs, viral load, CD4+ count, and drinking measures using Lifetime drinking history (LTDH), and Timeline Follow-back past 90 days (TLFB90) assessments were evaluated. Liver injury was also assessed in seven age- and sex-matched socially drinking HIV treatment-naïve patients who served as disease controls. Liver enzymes were significantly elevated in both AD+HIV and AD patients, and AD+HIV patients had significantly higher ALT levels than did AD patients, even with lower drinking. Serum zinc was significantly lower in AD+HIV patients. Only AD+HIV patients showed a significant elevation in linoleic acid (LA) and alpha-linoleic acid (ALA) levels. Serum zinc and ALT; LA and ALT; and ALA and ALT were significantly associated only in AD+HIV patients. The association between LA and ALT showed a higher effect than did the ALAand ALT association in the AD+HIV patients. Interestingly, AD+HIV subjects (who drank less) nevertheless showed more liver injury compared to AD patients, who reported heavier drinking. HIV viral load by itself did not show any correlation with liver injury. We speculate that the the underlying proinflammatory response resulting from zinc deficiency and an elevation in serum LA likely contributed to liver injury in AD+HIV patients, even with a comparatively lower degree of heavy drinking.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app