Polymorphism of PARP-1 indicates an increased risk and a worse initial severity of ischemic stroke.

AIM: Polymorphisms of DNA repair enzyme gene may alter the ability to repair damage and in turn may contribute to ischemic stroke susceptibility and outcome.

METHODS: We selected 316 ischemic stroke patients and 302 healthy controls. Then we genotyped SNPs of PARP-1 rs3219119, rs2271347 and APE1 rs1130409 in patient and control groups.

RESULTS: Polymorphism in PARP-1 rs2271347 was significantly associated with increased ischemic stroke risk (additive model: OR: 1.74; 95% CI: 1.03-2.93; p = 0.037). Patients harboring the PARP-1 rs2271347 GA/AA genotype had a worse initial stroke (additive model: OR: 1.85; 95% CI: 1.10-3.11; p = 0.021).

CONCLUSION: Our study suggests that genetic variant of rs2271347 may contribute to the etiology of ischemic stroke.