Impact of genetic variants of GLCCI1 on operational therapy in Chinese chronic rhinosinusitis patients.

BACKGROUND: Endoscopic surgery and postoperative glucocorticoids may effectively control inflammation in patients with chronic rhinosinusitis (CRS). However, some patients who are insensitive to glucocorticoids have a poor prognosis. Studies have shown that the GLCCI1 polymorphism is related to sensitivity to glucocorticoids, but no study has been conducted in China to investigate the relationship between GLCCI1 polymorphisms and postoperative prognosis of CRS.

METHODS: A total of 208 CRS patients received routine functional endonasal sinus surgery and then were treated with glucocorticoids. Polymerase chain reaction-restriction fragment length polymorphism was employed to detect the rs37973G/A polymorphism of GLCCI1. The visual analogue scale (VAS) score, Lund-Kennedy score, and computed tomography (CT) Lund-Mackay score were determined 6 months after surgery among patients with different genotypes. Moreover, the polymorphism frequency was compared among different subgroups.

RESULTS: There were no marked differences in VAS score, Lund-Kennedy score, or CT Lund-Mackay score among patients with different genotypes before surgery. In patients with the AA genotype, the changes in VAS score, Lund-Kennedy score, and CT Lund-Mackay scores were significantly higher than in patients with the GA/GG genotype (p < 0.05). However, there were no marked differences between patients with the GA genotype and those with the GG genotype (p > 0.05). Compared with patients with non-eosinophilic sinusitis, the difference between the AA genotype and the GA/GG genotype was more evident in patients with eosinophilic sinusitis (p < 0.01).

CONCLUSION: The rs37973 polymorphism is related to postoperative recovery from CRS for individual sensitivity to glucocorticoids. Furthermore, AA genotype was associated with better treatment response in CRS.