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LSD1 inhibitors disrupt the GFI1 transcription repressor complex.

Alba Maiques-Diaz, James T Lynch, Gary J Spencer, Tim C P Somervaille
Molecular & Cellular Oncology 2018
Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.

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