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Clinical value of 99m Tc-HYNIC-TOC SPECT/CT for the diagnosis primary small cell neuroendocrine carcinomas of the nasal cavity and paranasal sinuses.
Clinical Imaging 2018 September 21
PURPOSE: To evaluate the diagnostic value of 99m Tc-HYNIC-TOC SPECT/CT in the detection of primary small cell neuroendocrine carcinomas of the nasal cavity and paranasal sinuses.
METHODS: From September 2005 to November 2015, 19 patients (mean age 53.9 years, range 37-77; male 6, female 13) with sinonasal small cell neuroendocrine carcinoma (SNEC) underwent whole-body 99m Tc-HYNIC-TOC SPECT/CT scan.
RESULTS: All 19 primary lesions were detected by 99m Tc-HYNIC-TOC SPECT/CT. A total of 212 metastatic lesions were identified by organ-based analysis, and the sensitivity and specificity of 99m Tc-HYNIC-TOC SPECT/CT were 90.5% and 92.3%, respectively. The application of 99m Tc-HYNIC-TOC SPECT/CT resulted in the detection of a higher number of lesions in 11 patients (57.9%) and in the successful alteration of the treatment in 7 patients (36.8%) compared with the morphological imaging methods.
CONCLUSION: 99m Tc-HYNIC-TOC scintigraphy is an effective method for the detection of the sinonasal SNEC.
METHODS: From September 2005 to November 2015, 19 patients (mean age 53.9 years, range 37-77; male 6, female 13) with sinonasal small cell neuroendocrine carcinoma (SNEC) underwent whole-body 99m Tc-HYNIC-TOC SPECT/CT scan.
RESULTS: All 19 primary lesions were detected by 99m Tc-HYNIC-TOC SPECT/CT. A total of 212 metastatic lesions were identified by organ-based analysis, and the sensitivity and specificity of 99m Tc-HYNIC-TOC SPECT/CT were 90.5% and 92.3%, respectively. The application of 99m Tc-HYNIC-TOC SPECT/CT resulted in the detection of a higher number of lesions in 11 patients (57.9%) and in the successful alteration of the treatment in 7 patients (36.8%) compared with the morphological imaging methods.
CONCLUSION: 99m Tc-HYNIC-TOC scintigraphy is an effective method for the detection of the sinonasal SNEC.
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