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Three-component synthesis of a library of m-terphenyl derivatives with embedded β-aminoester moieties.
ACS Combinatorial Science 2018 September 25
The three-component reaction between alkyl- or arylamines, β-ketoesters and chalcones in refluxing ethanol containing a catalytic amount of Ce(IV) ammonium nitrate allowed the construction of a large library of highly substituted dihydro-m-terphenyl derivatives containing β-alkylamino- or β-arylamino ester moieties. This process generates three new bonds and one ring and proceeds in high atom economy, having two molecules of water as the only side product. Another domino process, in which the original MCR was telescoped with a subsequent aza Michael/retro-aza Michael sequence, allowed the one-pot preparation of a library of compounds with a N-unsubstituted β-aminoester fragment. Finally, in order to extend the structural diversity of these libraries, we also examined the aromatization of the central ring of our compounds in the presence of DDQ.
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