[Selected indicators of inflammation in patients hospitalized with various degrees of obesity and metabolic syndrome].

In people with metabolic syndrome, obesity and diseases of the cardiovascular system are more often observed. At the basis of the pathogenesis of the metabolic syndrome, chronic inflammation plays a significant role. One of the markers of this process is C-reactive protein (CRP) - one of the indicators of the acute phase of inflammation. The role of other biochemical parameters in obesity has been less well understood.

AIM: The aim of the study is to assess the correlation of selected factors of inflammation in obese people and the relevant anthropometric parameters.

MATERIALS AND METHODS: 263 patients participated in the study. In all subjects anthropometric measurements (body weight, waist/hip ratio and body mass index) were performed and selected biochemical parameters related to MS were determined. The obtained data were analyzed with the division into three degrees of obesity, taking into account gender and place of residence.

RESULTS: The mean C-reactive protein (CRP) concentration was 5,32 ± 14 mg/dl; in women, the highest concentration in 2° of obesity (5mg/dL) and in men in 1-potency (8,41mg/dL). A statistically significant difference in the level of leukocytes between 1° and 3° of obesity in the study group was obtained (p = 0,02). In 3° of obesity in both sexes the highest concentration of monocytes was demonstrated. Positive correlations between leukocyte levels and individual parameters were demonstrated: triglyceride levels (r = 0,134); and the BMI value (r = 0,155); a waist (r = 0,147); and the level of PLT (r = 0,381) and RBC (r = 0,187).

CONCLUSIONS: The consequence of obesity is the continuous production of inflammatory factors causing destruction of the body's own tissues. In the present study, CRP values were shown to slightly exceed (p<0,05) above the accepted norm, while the remaining analyzed indicators were within diagnostic standards (in their upper ranges).