IL-4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes.

IL-4 plays an important role in atopic dermatitis (AD) pathogenesis by dysregulating many key factors at the transcriptional level. In this study, using microRNA array technique and IL-4 transgenic mice, we demonstrated that IL-4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphoangiogenesis and apoptosis. Of all the 372 common microRNAs examined, 26 and 1 microRNAs are up- and down-regulated, respectively. MicroRNA-101-5p, -122-5p, -142-3p, -204-5p, -335-3p, -376a-3p, -378a-5p, -639 and -9-5p are among the most significantly up-regulated microRNAs. MicroRNA-147a, the only down-regulated one in our study, attenuates TLR induced-inflammatory response. These dysregulated microRNAs may provide post-transcriptional regulation of key genes in AD.