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JOURNAL ARTICLE
REVIEW
CONTRIBUTIONS OF NOCIRESPONSIVE AREA 3A TO NORMAL AND ABNORMAL SOMATOSENSORY PERCEPTION.
Journal of Pain 2018 September 16
Traditionally, cytoarchitectonic area 3a of primary somatosensory cortex (SI) has been regarded as a proprioreceptive relay to motor cortex. However, neuronal spike train recordings and optical intrinsic signal imaging, obtained from nonhuman sensorimotor cortex, show that neuronal activity in some of cortical columns in area 3a can be readily triggered by C-nociceptor afferent drive. These findings indicate that area 3a is a critical link in cerebral cortical encoding of 2nd /slow pain. Also, area 3a contributes to abnormal pain processing in the presence of activity-dependent reversal of GABAA receptor-mediated inhibition. Accordingly, abnormal processing within area 3a may contribute mechanistically to generation of clinical pain conditions.
PERSPECTIVE: Optical imaging and neurophysiological mapping of area 3a of primary somatosensory cortex (SI) has revealed substantial driving from unmyelinated cutaneous nociceptors, complementing input to areas 3b and 1 of SI from myelinated nociceptors and non-nociceptors. These and related findings force a reconsideration of mechanisms for SI processing of pain.
PERSPECTIVE: Optical imaging and neurophysiological mapping of area 3a of primary somatosensory cortex (SI) has revealed substantial driving from unmyelinated cutaneous nociceptors, complementing input to areas 3b and 1 of SI from myelinated nociceptors and non-nociceptors. These and related findings force a reconsideration of mechanisms for SI processing of pain.
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