Crystal structure of tebipenem pivoxil.

The mol-ecular structure of the first orally active carbapenem anti-bacterial agent, tebipenem pivoxil (systematic name: (2,2-di-methyl-propano-yloxy)methyl (4 R ,5 S ,6 S )-3-{[1-(4,5-di-hydro-1,3-thia-zol-2-yl)azetidin-3-yl]sulfanyl}-6-[(1 R )-1-hy-droxy-eth-yl]-4-methyl-7-oxo-1-aza-bicyclo-[3.2.0]hept-2-ene-2-carboxyl-ate), C22 H31 N3 O6 S2 , has been determined and the configurations of the four chiral centers validated. The title compound crystallizes in the triclinic space group P 1 with one mol-ecule in the unit cell. Three out of the four rings adopt planar conformations while the thia-zolinyl ring adopts an enveloped conformation. In the crystal, O-H⋯N hydrogen bonds link the mol-ecules into chains along [10].