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Relationship between IGF2BP2 and IGFBP3 polymorphisms and susceptibility to non-small-cell lung cancer: a case-control study in Eastern Chinese Han population.

Background: IGF2BP2 and IGFBP3 polymorphisms may be associated with cancer risk.

Methods: With an aim to determine the association of variations in IGF2BP2 and IGFBP3 genes with risk of non-small-cell lung cancer (NSCLC), IGF2BP2 rs1470579 A>C, rs4402960 G>T and IGFBP3 rs2270628 C>T, rs3110697 G>A, and rs6953668 G>A polymorphisms were selected and genotyped in 521 NSCLC patients and 1,030 controls.

Results: We found that there was no difference in IGF2BP2 and IGFBP3 genotype distribution among the NSCLC patients and controls. The stratified analyses suggested that IGF2BP2 rs1470579 A>C polymorphism decreased the risk of NSCLC in some subgroups (female subgroup: CC vs AA: adjusted P =0.032 and CC vs AC/AA: adjusted P =0.028; <60 years subgroup: CC vs AA: adjusted P =0.012 and CC vs AC/AA: adjusted P =0.013; and never drinking subgroup: CC vs AA: adjusted P =0.046 and CC vs AC/AA: adjusted P =0.031). The stratified analyses also found that IGF2BP2 rs4402960 G>T polymorphism decreased the risk of NSCLC in some subgroups (female subgroup: TT vs GG: adjusted P =0.031 and TT vs GT/GG: adjusted P =0.026; <60 subgroup: TT vs GG: adjusted P =0.037 and TT vs GT/GG: adjusted P =0.038; and never drinking subgroup: TT vs GT/GG: adjusted P =0.046). Haplotype analysis indicated Ars1470579 Crs2270628 Grs3110697 Grs4402960 Ars6953668 haplotype decreased susceptibility of NSCLC ( P =0.007).

Conclusion: Our study suggests that IGF2BP2 rs1470579 A>C, rs4402960 G>T single-nucleotide polymorphisms are candidates for decreased susceptibility to NSCLC among female, <60 years, and never drinking subgroups. In the future, more case-control studies with functional analysis are needed to confirm these preliminary findings.

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