The clinical trials of mesenchymal stem cell therapy in skin diseases: an update and concise review.

Skin is one of the crucial body organs which its anatomy and physiology are linked with various disorders including congenital or acquired diseases. Nowadays, mesenchymal stem cell (MSCs)-based therapy has become a promising therapeutic field, which is expected to help in the treatment of the most costly and incurable diseases. However, it could be questioned whether the use of MSCs has improved in clinical trials studies and diseases treatment. In this study, we review the clinical trials using MSCs in skin diseases. A remarkable number of clinical trial studies are in progress in this field, however, some have had early benefits to patients. We discuss here relevant papers and ongoing clinical trials that address MSC's therapeutic goals for various skin disorders, while this review can be very useful for both dermatologists and basic skin researchers, with the aim of contributing to stem cell-based therapeutic research in the area of skin disorders.