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Mitochondrial dsRNA: A New DAMP for MDA5.

Andreas Linder, Veit Hornung
Developmental Cell 2018 September 11
The role of mitochondria as a signaling platform downstream of the RNA sensors RIG-I and MDA5 is well defined. Now, a recent study in Nature by Dhir et al. (2018) identifies mitochondrial dsRNA as an immunogenic ligand, adding another intriguing aspect to the role of mitochondria in innate immunity.

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